Nicotinamide Riboside Chloride (NR) (23111-00-4) Soo-saaraha - Cofttek

Nicotinamide Riboside Chloride (NR) (23111-00-4)

April 7, 2020

Nicotinamide riboside, oo sidoo kale loo yaqaanno NR iyo SRT647, waa qaab loo yaqaan "Pyridine-nucleoside" oo ah fitamiin B3 kaasoo u shaqeynaya hormuud u ah nicotinamide adenine dinucleotide ama NAD +. NR wuxuu xannibayaa xumaanshaha qalliinka xididka 'ganglion neerons neurons ex vivo' wuxuuna ka ilaaliyaa maqalka dhawaqa maqal ee jiirarka nool.


Status: Wax soosaarka Mass
Unugga: 25kg / Drum

Nicotinamide Riboside Chloride (NR) (23111-00-4) fiidiyow

Nicotinamide Riboside Chloride (NR) Smamnuucista

Name: Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
xagiisayna 98%
Formula kelli: C11H15ClN2O5
Miisaankani waa: 290.7 g / mol
Dhibcaha Biyaha: 115-125 ℃
Magaca kiimikada: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
micne ah: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nikotinamide Riboside Triflate, α / β isku dar
Furaha gudaha: YABIFCKURFRPPO-FSDYPCQHSA-N
Kala badh: saacadood 2.7
Xalka: Dhibaatada DMSO, Methanol, Biyaha
Xaaladda Kaydinta: 0 - 4 C muddo gaaban (maalmo ilaa toddobaad), ama -20 C mudo dheer (bilo)
Codsiga: Nikotinamide riboside waxaa loo sheegaa inuu yahay nooc cusub oo ah pyridine-nucleoside oo ah fiitamiin B oo u shaqeynaya hor udhaca nicotinamide adenine dinucleotide ama NAD +.
Imaanshaha: Dufcaddii Caddaan oo Burcad Buruuruca ah ah

Waa maxay Nicotinamide Riboside Chloride (NR) CAS 23111-00-4?

Nicotinamide riboside, oo sidoo kale loo yaqaanno NR iyo SRT647, waa qaab loo yaqaan "Pyridine-nucleoside" oo ah fitamiin B3 kaasoo u shaqeynaya hormuud u ah nicotinamide adenine dinucleotide ama NAD +. NR wuxuu xannibayaa xumaanshaha qalliinka xididka 'ganglion neerons neurons ex vivo' wuxuuna ka ilaaliyaa maqalka dhawaqa maqal ee jiirarka nool. Nicotinamide riboside waxay ka hortageysaa muruqyada, neural iyo melanocyte stem cell senescence. Dib-u-cusboonaysiinta muruqyada jiirarka ayaa la arkay ka dib markii lagu daaweeyay nicotinamide riboside, taasoo horseedaysa la isla dhexmarayo in ay hagaajin karto dib-u-cusboonaysiinta xubnaha sida beerka, kelyaha, iyo wadnaha. Nicotinamide riboside sidoo kale waxay hoos u dhigtaa gulukooska dhiigga iyo beerka dufanka leh ee moodooyinka cudurka macaan iyo nooca 2 ee sonkorowga iyadoo laga hortagayo horumarka cudurka maskaxda ee maskaxda ee ku dhaca dareemayaasha. Xusuusin: Nikotinamide Riboside chloride waa isku dhaf α / β.

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 faa'iidooyin

Nikotinamide nucleosides waa horudhaca nicotinamide adenine dinucleotide (NAD) waxayna matalaan isha fitamiin B3. Daraasadihii ugu dambeeyay waxay muujiyeen in qaadashada qaddarka badan ee nicotinamide nucleosides si dabiici ah looga helo cuntooyinka ay bixin karto faa'iidooyin caafimaad oo cusub. Tusaale ahaan, nicotinamide nucleosides waxaa lagu cabiray kordhinta unugyada NAD iyo soo saarida xasaasiga insulin iyo sidoo kale kor u qaadida shaqada sirtuin. Awoodeeda ah inay kordhiso wax soo saarka NAD waxay soo jeedineysaa in nicotinamide nucleosides ay sidoo kale hagaajin karto caafimaadka mitochondrial, waxay kicin kartaa shaqada mitochondrial, waxayna kicineysaa soosaarka mitochondria cusub. Daraasado kale oo la isticmaalay nicotinamide nucleosides ee cudurka cudurka Alzheimer ayaa muujisay in molikalku u fiican yahay maskaxda isla markaana ay ku siin karto neuroprotection iyadoo la kicinayo maskaxda NAD.

Nicotinamide Riboside Chloride sidoo kale waxay yareyn kartaa culeyska: Daraasadaha ayaa muujiyay in marka aad kordhiso dheef-shiid kiimikaadka, aad si wax-ku-ool ah u yarayn karto cunnada dufanka badan ee ducanta badan. Si loo qiimeeyo habka nicotinamide ribose ee NR kor u qaadida culeyska, cilmi-baarayaashu waxay cabbireen shaqada beerka ee mitochondrial ee la xariira qaadashada kalooriga, waxqabadka, kaloorida, wareegga dhexda, xaddiga dheef-shiid kiimikaadka, jirku ka kooban yahay, dulqaad gulukoos ah, dareenka insulin-ta iyo kimikooyin kala duwan iyo metabolomics cabiraadaha. Xogtan iyo habka cusub ee miisaan lumis ee malabsorption, ka fogaanshaha calaamadaha noolaha ee raadraaca. Baarayaasha waxaay sheegeen in jiirka nicotinamide nicotinamide kaabisyada ay si aad ah ugu badan tahay inay lumiyaan culeyska ay kujiraan jiirarka aan buuxin nicotinamide.

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Farsamooyinka Ficil?

Nikotinamide Riboside Chloride (NR) nucleosides ayaa hormar u ah nicotinamide adenine dinucleotide (NAD) waxayna matalaan isha fitamiin B3. Daraasadihii ugu dambeeyay waxay muujiyeen in qaadashada qaddarka badan ee nicotinamide nucleosides si dabiici ah looga helo cuntooyinka ay bixin karto faa'iidooyin caafimaad oo cusub. Tusaale ahaan, nicotinamide nucleosides waxaa lagu cabiray kordhinta unugyada NAD iyo soo saarida xasaasiga insulin iyo sidoo kale kor u qaadida shaqada sirtuin. Awoodeeda ah inay kordhiso wax soo saarka NAD waxay soo jeedineysaa in nicotinamide nucleosides ay sidoo kale hagaajin karto caafimaadka mitochondrial, waxay kicin kartaa shaqada mitochondrial, waxayna kicineysaa soosaarka mitochondria cusub. Daraasado kale oo la isticmaalay nicotinamide nucleosides oo kujira nooca cudurka Alzheimer ayaa muujisay in molikalku ujiheysto maskaxda uuna ku siin karo neuroprotection isagoo kicinaya maskaxda NAD synthesis ..

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Codsiga

Daraasadaha horudhaca ah waxay muujiyeen in ku darista nikotiinka loo yaqaan 'nicotinamide ribose' aysan kaliya kordhin karin heerarka NAD +, laakiin sidoo kale ay kor u qaaddo isticmaalka NAD + ee aadanaha, taas oo aan suurtagal ahayn marka la qaato fiitamiinnada kale ee B3.Studies ayaa muujisay in mar nicotinamide ribose ay ka muuqato unugga, jirku si dhakhso ah ayuu ugu beddelaa NAD +. NAD + ka dib waxay kiciyaan geedi socodka horudhaca intracellular ee soosaarka tamarta by mitochondria

Nicotinamide Riboside Chloride waxay kor u qaadi kartaa shaqada mitochondrial, taas oo la muujiyey inay kor u qaaddo muujinta borotiinka gaadiidka mitochondrial, kor u qaaddo awoodda mitochondrial xuubka, iyo kordhinta heerka neefsashada ee oxidative iyo heerarka ATP ee intracellular. Tan waxaa la socon kara heerar sare oo ah cusboonaysiinta mitochondrial. Shaqada Mitochondrial ayaa hoos u dhacda markaynu sii weynaaneyno, waana tan calaamadda u ah gabowga unugyada asliga ah ee aan helno. NR waxay kor u qaadeysaa shaqada mitochondria waxayna xayiraysaa dareemayaasha unugyada asliga ah.

Nicotinamide Riboside Chloride (NR) budo for sale(Xagee laga iibsadaa Nikotinamide Riboside Chloride (NR) budo badan)

Shirkaddayadu waxay ku raaxeysataa xiriirro waqti dheer leh macaamiisheena maxaa yeelay waxaan diiradda saareynaa adeegga macaamiisha iyo bixinta alaabada waa weyn. Haddii aad xiiseyneyso badeecadeena, waxaan la qabsaneynaa qaabaynta amarrada ku habboon baahiyahaaga gaarka ah iyo waqtigeenna dhakhsaha ah ee hoggaanka amarada dammaanad-qaadista waxaad kuheli doontaa cuntadeena waqtigeeda waqtigeeda. Waxaan sidoo kale diirada saareynaa adeegyada qiimeynta ku jira. Waxaan diyaar u nahay su'aalaha adeegga iyo macluumaadka si aan u taageerno meheraddaada.

Waxaan nahay khabiir Nikotinamide Riboside Chloride (NR) iibiyaha budada dhowr sano, waxaan siineynaa badeecado leh qiime tartan, iyo badeecaddeenu waa midda ugu tayada sareysa waxaynana maraysa tijaabooyin adag, madax-bannaan si loo hubiyo inay aamin u tahay isticmaalka adduunka oo dhan.

tixraacyada

  • Chi Y, Sauve AA. Nikotinamide riboside, oo ah raad nafaqo ku leh cuntooyinka, waa fiitamiin B3 oo saameyn ku leh dheef-shiid kiimikaadka iyo neuroprotection. Daryeelka Curr Opin Clin Nutr Metab Care. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Dib u eegis PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, iyo nicotinamide riboside: qiimeynta molikalikada ee NAD + fiitamiinnada hormarsan ee nafaqada aadanaha. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Dib u eegis PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation oo ah unug-intrinsic ah, darawalka korniinka ee keydinta dufanka: kiimikada iyo caqliga dheef-shiid kiimikaadka isbeddelada acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Noof-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Dib u eegis PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Waxkasta oo aad u Baahan Tahay Inaad Ka Ogaato Nikotinamide Riboside Chloride