Budada NR (23111-00-4)

April 7, 2020

Nicotinamide riboside, oo sidoo kale loo yaqaanno NR iyo SRT647, waa qaab loo yaqaan "Pyridine-nucleoside" oo ah fitamiin B3 kaasoo u shaqeynaya hormuud u ah nicotinamide adenine dinucleotide ama NAD +. NR wuxuu xannibayaa xumaanshaha qalliinka xididka 'ganglion neerons neurons ex vivo' wuxuuna ka ilaaliyaa maqalka dhawaqa maqal ee jiirarka nool.

 


Status: Wax soosaarka Mass
Unugga: 1kg / bac, 25kg / Drum

 

Budada NR (23111-00-4) fiidiyow

 

Nicotinamide Riboside Chloride (NR) Smamnuucista

Name: Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
xagiisayna 98%
Qaaciddada Molecular: C11H15ClN2O5
Miisaanka kelli: 290.7 g / mol
Dhibcaha Biyaha: 115-125 ℃
Magaca kiimikada: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
micne ah: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nikotinamide Riboside Triflate, α / β isku dar
Furaha gudaha: YABIFCKURFRPPO-FSDYPCQHSA-N
Kala badh: saacadood 2.7
Xalka: Dhibaatada DMSO, Methanol, Biyaha
Xaaladda Kaydinta: 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo), ama -20 C muddo dheer (bilo)
Codsiga: Nikotinamide riboside waxaa loo sheegaa inuu yahay nooc cusub oo ah pyridine-nucleoside oo ah fiitamiin B oo u shaqeynaya hor udhaca nicotinamide adenine dinucleotide ama NAD +.
Imaanshaha: Dufcaddii Caddaan oo Burcad Buruuruca ah ah

 

Waa maxay budada Nicotinamide Riboside Chloride budada CAS 23111-00-4?

Nicotinamide riboside, oo sidoo kale loo yaqaanno NR iyo SRT647, waa qaab loo yaqaan "Pyridine-nucleoside" oo ah fitamiin B3 kaasoo u shaqeynaya hormuud u ah nicotinamide adenine dinucleotide ama NAD +. NR wuxuu xannibayaa xumaanshaha qalliinka xididka 'ganglion neerons neurons ex vivo' wuxuuna ka ilaaliyaa maqalka dhawaqa maqal ee jiirarka nool. Nicotinamide riboside waxay ka hortageysaa muruqyada, neural iyo melanocyte stem cell senescence. Dib-u-cusboonaysiinta muruqyada jiirarka ayaa la arkay ka dib markii lagu daaweeyay nicotinamide riboside, taasoo horseedaysa la isla dhexmarayo in ay hagaajin karto dib-u-cusboonaysiinta xubnaha sida beerka, kelyaha, iyo wadnaha. Nicotinamide riboside sidoo kale waxay hoos u dhigtaa gulukooska dhiigga iyo beerka dufanka leh ee moodooyinka cudurka macaan iyo nooca 2 ee sonkorowga iyadoo laga hortagayo horumarka cudurka maskaxda ee maskaxda ee ku dhaca dareemayaasha. Xusuusin: Nikotinamide Riboside chloride waa isku dhaf α / β.

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 faa'iidooyin

Nikotinamide nucleosides waa horudhaca nicotinamide adenine dinucleotide (NAD) waxayna matalaan isha fitamiin B3. Daraasadihii ugu dambeeyay waxay muujiyeen in qaadashada qaddarka badan ee nicotinamide nucleosides si dabiici ah looga helo cuntooyinka ay bixin karto faa'iidooyin caafimaad oo cusub. Tusaale ahaan, nicotinamide nucleosides waxaa lagu cabiray kordhinta unugyada NAD iyo soo saarida xasaasiga insulin iyo sidoo kale kor u qaadida shaqada sirtuin. Awoodeeda ah inay kordhiso wax soo saarka NAD waxay soo jeedineysaa in nicotinamide nucleosides ay sidoo kale hagaajin karto caafimaadka mitochondrial, waxay kicin kartaa shaqada mitochondrial, waxayna kicineysaa soosaarka mitochondria cusub. Daraasado kale oo la isticmaalay nicotinamide nucleosides ee cudurka cudurka Alzheimer ayaa muujisay in molikalku u fiican yahay maskaxda isla markaana ay ku siin karto neuroprotection iyadoo la kicinayo maskaxda NAD.

Nicotinamide Riboside Chloride sidoo kale waxay yareyn kartaa miisaanka: Daraasaduhu waxay muujiyeen in adoo kordhiya dheef-shiid kiimikaadka, aad si wax ku ool ah u yareyn karto cunnada dufanka badan ee culeyskiisu kordho. Si loo qiimeeyo habka loo yaqaan 'nicotinamide ribose' ee NR ee kor u qaadista miisaanka, cilmi baarayaashu waxay qiyaaseen shaqada mitochondrial beerka ee la xiriirta qaadashada kalooriga, firfircoonida, kalooriyada, wareega dhexda, nasashada sicirka dheef-shiid kiimikaadka, isku-dhafka jirka, dulqaadka gulukooska, xasaasiyadda insulin iyo biochemical iyo metabolomics kala duwan. xuduudaha Xogtaan iyo habka miisaanka luminta cusub ee malabsorption, soo saarista astaamaha bayoolojiga si loola socdo. Cilmi baarayaashu waxay soo sheegeen in jiirka la quudin jiray nicotinamide nicotinamide supplements ay aad ugu dhowdahay inuu lumiyo miisaankiisa marka loo eego jiirka aan ku darin nicotinamide

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Farsamooyinka Ficil?

Nicotinamide Riboside Chloride (NR) nucleosides waa horudhaca nicotinamide adenine dinucleotide (NAD) waxayna matalaan isha fiitamiin B3. Daraasadihii ugu dambeeyay waxay muujiyeen in qaadashada qaddar badan oo ah nicotinamide nucleosides si dabiici ah ugu jira cuntooyinka ay ku siin karaan faa'iidooyin caafimaad oo cusub. Tusaale ahaan, nikotinamide nucleosides waxaa lagu soo koobay kordhinta nudaha unugyada 'NAD' iyo soosaarida xasaasiyadda insulin iyo sidoo kale xoojinta shaqada sirtuin. Awoodda ay u leedahay inay kordhiso wax soo saarka NAD waxay soo jeedineysaa in nicotinamide nucleosides uu sidoo kale hagaajin karo caafimaadka mitochondrial, kicin karo shaqada mitochondrial, uuna dhali karo soosaarka mitochondria cusub. Daraasado kale oo loo adeegsado nikotinamide nucleosides oo ku jira qaabka cudurka Alzheimers ayaa muujiyey in mecuulku yahay mid la heli karo maskaxda oo laga yaabo inuu ku siiyo neuroprotection adoo kicinaya maskaxda isku-darka NAD ..

 

 

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Codsiga

Daraasadaha horudhaca ah waxay muujiyeen in ku darista nikotiinka loo yaqaan 'nicotinamide ribose' aysan kaliya kordhin karin heerarka NAD +, laakiin sidoo kale ay kor u qaaddo isticmaalka NAD + ee aadanaha, taas oo aan suurtagal ahayn marka la qaato fiitamiinnada kale ee B3.Studies ayaa muujisay in mar nicotinamide ribose ay ka muuqato unugga, jirku si dhakhso ah ayuu ugu beddelaa NAD +. NAD + ka dib waxay kiciyaan geedi socodka horudhaca intracellular ee soosaarka tamarta by mitochondria

Nicotinamide Riboside Chloride waxay kor u qaadi kartaa shaqada mitochondrial, taas oo la muujiyey inay kor u qaaddo muujinta borotiinka gaadiidka mitochondrial, kor u qaaddo awoodda mitochondrial xuubka, iyo kordhinta heerka neefsashada ee oxidative iyo heerarka ATP ee intracellular. Tan waxaa la socon kara heerar sare oo ah cusboonaysiinta mitochondrial. Shaqada Mitochondrial ayaa hoos u dhacda markaynu sii weynaaneyno, waana tan calaamadda u ah gabowga unugyada asliga ah ee aan helno. NR waxay kor u qaadeysaa shaqada mitochondria waxayna xayiraysaa dareemayaasha unugyada asliga ah.

 

NR budo for sale(Xagee laga iibsadaa Nikotinamide Riboside Chloride (NR) budo badan)

Shirkaddayadu waxay ku raaxeysataa xiriirro waqti dheer leh macaamiisheena maxaa yeelay waxaan diiradda saareynaa adeegga macaamiisha iyo bixinta alaabada waa weyn. Haddii aad xiiseyneyso badeecadeena, waxaan la qabsaneynaa qaabaynta amarrada ku habboon baahiyahaaga gaarka ah iyo waqtigeenna dhakhsaha ah ee hoggaanka amarada dammaanad-qaadista waxaad kuheli doontaa cuntadeena waqtigeeda waqtigeeda. Waxaan sidoo kale diirada saareynaa adeegyada qiimeynta ku jira. Waxaan diyaar u nahay su'aalaha adeegga iyo macluumaadka si aan u taageerno meheraddaada.

 

Waxaan nahay khabiir Nikotinamide Riboside Chloride (NR) iibiyaha budada dhowr sano, waxaan siineynaa badeecado leh qiime tartan, iyo badeecaddeenu waa midda ugu tayada sareysa waxaynana maraysa tijaabooyin adag, madax-bannaan si loo hubiyo inay aamin u tahay isticmaalka adduunka oo dhan.

 

tixraacyada

  • Chi Y, Sauve AA. Nikotinamide riboside, oo ah raad nafaqo ku leh cuntooyinka, waa fiitamiin B3 oo saameyn ku leh dheef-shiid kiimikaadka iyo neuroprotection. Daryeelka Curr Opin Clin Nutr Metab Care. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Dib u eegis PubMed PMID: 24071780.
  • Bogan KL, Brenner C. Nicotinic acid, nicotinamide, iyo nicotinamide riboside: qiimeynta molikalikada ee NAD + fiitamiinnada hormarsan ee nafaqada aadanaha. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Dib u eegis PubMed PMID: 18429699.
  • Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation oo ah unug-intrinsic ah, darawalka korniinka ee keydinta dufanka: kiimikada iyo caqliga dheef-shiid kiimikaadka isbeddelada acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Noof-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Dib u eegis PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • Waxkasta oo aad u Baahan Tahay Inaad Ka Ogaato Nikotinamide Riboside Chloride