Soosaaraha ugu fiican Soosaaraha budada Pyridoxal hydrochloride

Pyridoxal hydrochloride (65-22-5)

Waxaa laga yaabaa 11, 2021

Cofttek waa soosaaraha ugu fiican ee Pyridoxal hydrochloride ee Shiinaha. Warshadeena waxay leedahay nidaam maareyn wax soo saar oo dhameystiran (ISO9001 & ISO14001), oo leh awood wax soo saar bille ah oo ah 320kg.

 


Status: Wax soosaarka Mass
Unugga: 1kg / bac, 25kg / Drum

Pyridoxal hydrochloride (65-22-5) Smamnuucista

Name: Pyridoxal hydrochloride
CAS: 65-22-5
xagiisayna 98%
Qaaciddada Molecular: C8H10ClNO3
Miisaanka kelli: 203.622 g / mol
Dhibcaha Biyaha: 173 ° C
Magaca kiimikada: PYRIDOXAL HYDROCLORIDE

Pyridoxal HCl 3-Hydroxy-5- (hydroxymethyl) -2-methylisonicotinaldehyde hydrochloride

micne ah: 3-hydroxy-5- (hydroxymethyl) -2-methyl-4-pyridinecarboxaldehyde hydrochloride / Pyridoxal HCl
Furaha gudaha: FCHXJFJNDJXENQ-UHFFFAOYSA-N
Kala badh: N / A
Xalka: Ku milma biyaha
Xaaladda Kaydinta: 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo), ama -20 C muddo dheer (bilo)
Codsiga: Waxaa loo baahan yahay si loo ilaaliyo caafimaadka dareemayaasha, maqaarka, iyo unugyada dhiigga cas. Pyridoxine waxaa loo isticmaalay in laga hortago ama lagu daaweeyo cilad gaar ah oo ku timaadda dareemayaasha (peripheral neuropathy) oo ay keento daawooyinka qaarkood (sida isoniazid).
Imaanshaha: Caddaan budada cad-cad

 

Pyridoxal hydrochloride (65-22-5) Spectrum NMR

Pyridoxal hydrochloride (65-22-5)

Haddii aad u baahan tahay COA, MSDS, HNMR qayb kasta oo badeecad ah iyo macluumaad kale ah, fadlan la soo xiriir annaga maareeyaha suuq gaynta.

 

Waa maxay Pyridoxal Hydrochloride?

Pyridoxal hydrochloride waa nooc ka mid ah fitamiin B6. Sida qaabka 4-carbaldehyde ee fitamiin B6, waxaa lagu sameeyaa iyadoo lagu qaso pyridoxal iyo hal molar oo u dhiganta hydrochloric acid. Waa kaab nafaqo. Qaabka kiimikaadkeedu waa C8H10ClNO3. Magaceeda IUPAC waa 3-hydroxy-5-(hydroxymethyl) -2-methyl pyridine-4-carbaldehyde hydrochloride.

Walaxdaani waxay iska leedahay fasalka isku dhafka dabiiciga ah ee loo yaqaan pyridoxal iyo asalkiisa. Kuwaas waxaa ku jira unug pyridoxal ah oo leh giraanta pyridine oo leh beddelaadyo kala duwan. Qodobbada beddelka ah waxaa ka mid ah kooxda methyl ee booska 2, kooxda hydroxyl ee booska 3, kooxda carbaldehyde ee booska 4, iyo kooxda hydroxymethyl ee booska 5.

Pyridoxal hydrochloride waxaa loo isticmaalaa daawaynta nephropathy macaanka. Waxaa loo baahan yahay si loo ilaaliyo caafimaadka neerfaha, maqaarka, iyo unugyada dhiigga cas. Waxa uu jidhku u isticmaalaa in uu sameeyo neurotransmitters sida serotonin iyo norepinephrine. Waxa kale oo ay caawisaa in la sameeyo sphingolipids iyo aminolevulinic acid. Pyridoxal hydrochloride waxa loo beddelaa pyridoxal 5-fosfate, koenzyme ka samaysan asiidhyada amino.

Maadaama fitamiin B6 uusan soo saari karin jirka, waxay u baahan tahay in laga isticmaalo ilo kala duwan ama iyada oo loo marayo kaabis. Waxay u jirtaa qaabab badan mid ka mid ah waa pyridoxal kaas oo ah qaab 4-carboxaldehyde ah oo fitamiin B6 ah iyo sidoo kale qaybiye hawlo badan oo dheef-shiid kiimikaad ah.

Pyridoxal hydrochloride waa nooc cusbo ah oo pyridoxal ah waxaana si diyaar ah loogu beddelaa fosfatka pyridoxal kaas oo sidoo kale loo yaqaan PLP ka dib maamulka oo u shaqeeya sida coenzyme ee dhaqdhaqaaqa dheef-shiid kiimikaadka.

 

Sidee Pyridoxal Hydrochloride u shaqeysaa?

Faytamiin B6 waxa uu leeyahay saddex nooc oo dabiici ah: pyridoxine, pyridoxal, iyo pyridoxamine, kuwaas oo dhamaantood isu beddela qaabkooda firfircoon ee jidhka waxaana loo yaqaan pyridoxal 5'-phosphate. Calaamadaha yaraanta fitamiin B6 waa seborrheic dermatitis, microcytic anemia, glossitis, gariir, neuropathy peripheral, niyad-jab, iwm. si loo buuxiyo fitamiin B6 ee jirka.

Pyridoxal hydrochloride waa horudhaca pyridoxal 5'-fosfate. Ka dib markii la isticmaalo pyridoxal hydrochloride, waxay isu beddeshaa pyridoxal 5-phosphate ee hepatocytes iyo unugyada xuubka mindhicirka. Ka dib waxaa qaadaya dhiigga oo loo qaybiyaa jirka oo dhan. Waxay ku lug leedahay noocyo badan oo falcelinta dheef-shiid kiimikaadka. Tan waxaa ka mid ah samaynta iyo dheef-shiid kiimikaadka amino acids iyo glycogen. Waxa kale oo ay kaa caawin kartaa in ay abuurto asiidhyada nucleic, hemoglobin, iyo neurotransmitters.

Pyridoxal 5'-phosphate waa coenzyme ku lug leh dheef-shiid kiimikaadka amino acid. Waxay u dhaqmaan sidii coenzyme oo kale dhammaan falcelinta gudbinta. Waxa kale oo ay ku lug leedahay oxidation iyo falcelinta deamination ee acids amino.

Kooxda aldehyde ee ku jirta pyridoxal 5'-phosphate waxay sameysaa isku xirka Schiff-saldhigga kooxda epsilon-amino ee koox gaar ah oo lysine ah oo ah enzymes aminotransferase. Kooxda alfa-amino ee substrate-ka amino acid ayaa markaa meesha ka saaraysa kooxda epsilon-amino. Tani waxay keenaysaa samaynta adimine, kaas oo ka soo baxa. Taas ka dib, waxay noqotaa dhexdhexaadiye quinoid ah kaas oo aqbala protons meelo kala duwan oo ugu dambeyntii noqda ketimine. Ketimine ka dib waxa lagu shubaa hydrolyzed si ay kooxda amino-ku ugu sii jiraan isku-xidhka borotiinka.

Pyridoxal hydrochloride sidoo kale waxay gacan ka geysataa abuurista neurotransmitters sida serotonin, dopamine, norepinephrine, iyo gamma-aminobutyric acid.

Pyridoxal hydrochloride wali uma oggolaan isticmaalka FDA.

 

Avv

Pyridoxal hydrochloride waxaa laga soo saaray falcelinta organic iyadoo ka falcelinaysa pyridoxamine hal molar oo ah hydrochloric acid. Pyridoxal hydrochloride sidoo kale waxaa lagu soo saari karaa iyada oo loo marayo oksaydheynta xulashada. Dareen-celinta waxay ka kooban tahay qaadashada pyridoxine hydrochloride oo ah walxo bilaw ah iyo habka oksaydhismka catalytic ayaa lagu fulin doonaa biyaha. Oksijiinta kicinta waxaa ka mid ah isha oksijiinta, kicinta, cusbo aan organic ahayn, iyo ligand amin. Wax soo saarka ugu dambeeya ee oksaydhisku wuxuu noqonayaa pyridoxal hydrochloride.

 

Pharmacokinetics ee Pyridoxal Hydrochloride

Muuqaalka: Waxay si fudud u nuugaan faafinta dadban oo nuuggoodu waxay inta badan ku kooban tahay unugyada xuubka mindhicirka kuwaas oo qani ku ah pyridoxine kinase iyo pyridoxal phosphate.

 

Dheef-shiid kiimikaad Inta badan xeryahooda dabiiciga ah waxaa qaada beerka, natiijada ka soo baxdana waxaa sameeya faafinta dhexdhexaadiyaha ah iyo dabinnada dheef-shiid kiimikaadka sida xeryahooda fosfate. Fosforyaalka xeryahooda waxay si fudud ugu dhacaan beerka.

 

qaybinta: Fosfooraska pyridoxal ee bilaashka ah ee beerka ku jira ayaa lagu shubaa pyridoxal, kaas oo ka dib la dhoofiyo oo ku xidha hemoglobin iyo albumin ee erythrocytes. Qaybta dephosphorylated waxay ka tagtaa unugga iyadoo faafinaysa sidaas darteed waxaa jiri doona ururin yar oo fosfate ah pyridoxal ee unugyada.

 

Soo saarista: Pyridoxal-ka bilaashka ah ee ku haray beerka ayaa si degdeg ah oksidized ilaa 4-pyridoxic acid waana sheyga ugu muhiimsan ee qashinka. Oxidation ilaa 4-pyridoxic acid waxaa dhexdhexaadiya aldehyde dehydrogenase, kaas oo si ballaaran ugu jira unugyo badan, oksaydhka waxaa sidoo kale qaada kelyaha iyo hepatic aldehyde oxidase enzymes. Waddada muhiimka ah ee soo saarista pyridoxal hydrochloride ka dib dheef-shiid kiimikaad waa kaadida.

 

Faa'iidooyinka Pyridoxal Hydrochloride

Waxaa jira dhowr isticmaal oo loo isticmaalo pyridoxal hydrochloride. Si kastaba ha ahaatee, inta badan adeegsiyadan ayaa weli ku socda cilmi-baaris oo looma tixgelin karo isticmaalka qeexan ee xaruntan.

Waa kuwan qaar ka mid ah faa'iidooyinka pyridoxal hydrochloride

 

Saamaynta xanuunka macaanka ee nephropathy

Wax soo saarka Pyridoxal hydrochloride pyridoxal 5'-phosphate waxay joojin kartaa samaynta alaabada dhamaadka glycation sare (AGEs). Tani waxay ku samaynaysaa iyada oo dabinaysa 3-deoxyglucosone. Daraasad lagu sameeyay jiirka macaanka ee streptozotocin, waxaa lagu daweeyay pyridoxal 5-phosphate muddo 16 toddobaad ah [1]. Natiijooyinku waxay muujiyeen hoos u dhac weyn oo ku yimid albuminuria, hypertrophy glomerular, ballaarinta mesangial, iyo fibrosis interstitial. Waxay kaloo hoos u dhigtay heerarka AGE-yada. Sidaa darteed, muddada dheer, pyridoxal hydrochloride waxay hoos u dhigi kartaa nephropathy ee ku dhaca sonkorowga.

 

Saamaynta Metabolite ahaan

Pyridoxal hydrochloride iyo pyrimidine 5'-fosfate waxay u dhaqmaan sida walxaha muhiimka ah ee loo baahan yahay inta lagu jiro falcelinta dheef-shiid kiimikaadka. Awooddooda inay u dhaqmaan sida coenzyme waxaa looga baahan yahay labadaba jirka bini'aadamka iyo sidoo kale noolaha iyo bakteeriyada kala duwan sida Escherichia coli, Saccharomyces cerevisiae, jiirarka. Waxay lagama maarmaan u yihiin inay soo saaraan xeryahooda kala duwan ee looga baahan yahay jirka.

 

Saamaynta Neurotransmitters

Pyridoxal hydrochloride waxay kaa caawin kartaa samaynta neurotransmitters kala duwan ee jirka.

 

Saamaynta Anemia

Dhiig-yarida qaarkood, fitamiin B6 ayaa lagama maarmaan u ah in lagu bixiyo kaab ahaan. Pyridoxal hydrochloride waxay kaa caawin kartaa bixinta pyridoxal 5'-phosphate lagama maarmaanka u ah si loo daaweeyo xaaladahan oo kale.

 

Isticmaalka Cilmi-baarista Caafimaadka

Pyridoxal 5'-fosfate, isku-dhafka ka-soo-baxa ee pyridoxal hydrochloride, ayaa lagama maarmaan u ah qaar ka mid ah bakteeriyada caafimaadka la xiriirta. Waa in la hubiyo korriimadooda saxda ah. Waxaa ka mid ah bakteeriyada sida Granulicatella iyo Abiotrophia [2]. Baahida nafaqada ee pyridoxal hydrochloride waxay sababi kartaa ifafaale dhaqameed ee koritaanka dayax-gacmeedka ee bakteeriyadan. Dhaqanka in vitro, bakteeriyadani waxay ka bixi kartaa oo keliya meelaha ay jiraan bakteeriyada kale ee samaysa pyridoxal. Mid ka mid ah qodobbada ugu muhiimsan ee ku saabsan xarunta pyridoxal waa in laga yaabo inay u soo baxday sidii fal-celinta dheef-shiid kiimikaadka aerobic-ka ee qadiimiga ah ee dhulka.

 

Saamaynta ay leedahay Pyridoxal Hydrochloride

  • Dareenka maqaarka
  • Feejignaanta
  • Xanaaqa neefsiga
  • Lalabbo
  • Matagid
  • Peripheral neuropathy
  • Dareenka oo yaraada
  • Madax
  • Kabuubis
  • Qulqulka
  • Calool xanaaq

 

Is dhexgalka Pyridoxal Hydrochloride ee Dawooyinka kale

Ma jiro xog ku filan oo ku saabsan isdhexgalka tooska ah ee pyridoxal hydrochloride ee daawooyinka kale. Si kastaba ha ahaatee, waxaa jira macluumaad la og yahay oo ku saabsan isku dhafka pyridoxal 5'-phosphate ee isdhexgalka daawooyinka kale.

Qaar ka mid ah isdhexgalkaan waa:

Amiodarone - Isdhexgalka pyridoxine 5'-phosphate, waxay kordhin kartaa dareenka iftiinka, taasoo keenta gubasho, iwm.

Phenytoin - Pyridoxine 5'-phosphate waxay kordhin kartaa dheef-shiid kiimikaad ee phenytoin ee jirka, taasoo keenaysa waxtarka dambe.

Phenobarbital Pyridoxine 5'-phosphate waxay kordhin kartaa waqtiga burburka ee phenobarbital.

Levodopa - Waxay keeni kartaa dheef-shiid kiimikaad degdeg ah ee levodopa.

Iyadoo la og yahay in yaraanta pyridoxine ay ku dhacdo uurka iyo naas nuujinta, ma jiraan wax macluumaad ah oo ku saabsan saameynta pyridoxal hydrochloride ee xaaladahan. Sidaa darteed, waxaa lagu talinayaa in la sameeyo taxaddar.

 

Halkee laga iibsan karaa Pyridoxal Hydrochloride 2021?

Waxaad si toos ah uga iibsan kartaa budada pyridoxal hydrochloride shirkadda pyridoxal hydrochloride. Waxaa lagu heli karaa xadiga 1kg kiishka ama 15kg halkii durbaan. Si kastaba ha ahaatee, tan waxaa lagu hagaajin karaa iyadoo loo eegayo baahida isticmaalaha. Budadani waxay u baahan tahay in lagu kaydiyo heerkul ah 0 ilaa 4 ° muddada gaaban iyo -20 °C muddada dheer.

Pyridoxal hydrochloride budada waxaa lagu heli karaa qaab budo midab cad ama ka baxsan. Waxaa lagu sameeyay maaddooyinka ugu wanagsan iyadoo si adag loo ilaalinayo si loo hubiyo in isticmaalayaashu helaan badeecada ugu fiican.

 

tixraacyada

  1. Nakamura, S., Li, H., Adijiang, A., Pischetsrieder, M., & Niwa, T. (2007). Pyridoxal fosfate waxay ka hortagtaa horumarka nephropathy macaanka. Qalliinka Neerfaha ee Qalitaanka Qalitaanka, 22(8), 2165-2174.
  2. Kitada, K., Okada, Y., Kanamoto, T., & Inoue, M. (2000). Noocyada serological ee Abiotrophia iyo noocyada Granulicatella (nafaqo ahaan kala duwanaansho streptococci). Microbiology iyo immunology, 44(12), 981-985.

 


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