Urolithin A Tilmaamaha budada
| Name: | Urolitin A |
| Magaca kiimikada: | 3,8-Dihydroxybenzo [c] chromen-6-kow |
| CAS: | 1143-70-0 |
| Caanaha Kiimikada: | C13H8O4 |
| Miisaankani waa: | 228.2 |
| Color: | Caddaan cad-cad oo budada ah |
| Keydka InChi: | RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| NOLOSHADA SMILES: | O=C1C2=CC(O)=CC=C2C3=C(O1)C=C(O)C=C3 |
| function: | Urolithin A, oo ah dheef-shiid kiimikaad-microbial-ka ah ee aaladda lulagic acid, wuxuu la dagaallamaa anti-bararka, antiproliferative, iyo guryaha antioxidant-ka. Urolithin A ayaa kadhigaysa is-beddel iyo isku-shaandhayn, waxay joojisaa horumarka wareegga unugyada, waxayna xannibtaa isu-imaatinka DNA. |
| Codsiga: | Urolithin A waa dheef-shiid kiimikaad leh ellagitannin; Farmashiyeyaasha Daawada |
| Xalka: | Dhibaatada DMSO (3 mg / mL). |
| Kaydinta Nabadgelyada: | Qalalan, madow iyo 0 - 4 C muddo gaaban (maalmo illaa toddobaadyo) ama -20 C muddo dheer (bilo illaa sannado). |
| Xaaladda Maraakiibta: | Nadiifi heerkulbeegyada heerkulka sida kiimiko aan halis lahayn. Badeecadani waa mid xasilloon oo ku filan muddo toddobaadyo ah inta lagu jiro maraakiibta caadiga ah iyo wakhtiga lagu kharash gareeyo. |
Urolitin A Spectrum NMR
Haddii aad u baahan tahay COA, MSDS, HNMR qayb kasta oo badeecad ah iyo macluumaad kale ah, fadlan la soo xiriir annaga maareeyaha suuq gaynta.
Hordhac Urolithins
Urolithins waa dheef-shiid kiimikaadka labaad ee ellagic acid ka soo jeeda ellagitannins. Bini'aadamka ellagitannins waxaa loo beddelaa microflora gut oo loo yaqaan 'ellagic acid' oo loo sii beddelo urolithins A, urolithin B, urolithin C iyo urolithin D oo ku jira mindhicirada waaweyn.
Urolithin A (UA) waa dheef-shiid kiimikaadka ugu badan ee ellagitannins. Si kastaba ha noqotee, urolithin A lama yaqaan inay si dabiici ah ugu dhacdo ilo cunto kasta.
Urolithin B (UB) waa dheef-shiid kiimikaad badan oo laga soo saaray mindhicirka iyada oo loo marayo isbeddelka ellagitannins. Urolithin B waa sheyga ugu dambeeya ka dib dhamaan waxyaabaha kale ee ka soo baxa urolithin waa la kaydiyaa. Urolithin B waxaa laga helaa kaadida oo ah urolithin B glucuronide.
Urolithin A 8-Methyl Ether waa badeecada dhexdhexaadka ah inta lagu gudajiro soo saarista Urolithin A. Waa dheef-shiid kiimikaad sare oo muhiim ah ellagitannin waxayna leedahay astaamo antioxidant iyo anti-bararka.
Mashruuca ficilka urolithin A iyo B
Rol Urolithin A ayaa dhalisa mitophagy
Mitophagy waa hal nooc oo iskeed ah oo caawisa ciribtirka mitochondrial waxyeelo soo gaartay shaqadooda ugu fiicnaa. Cudurka loo yaqaan 'autophagy' waxaa loola jeedaa nidaamka guud ee ay ku saleysan tahay cilmiga 'cytoplasmic' oo ku liitay isla markaana dib loo warshadaynayo halka mitophagy-ga uu yahay nabaad-guurka iyo dib-u-warshadaynta mitochondria.
Inta lagu jiro da'da hoos u dhaca autophagy waa hal dhinac oo horseedaya hoos u dhaca shaqada mitokondria. Dheeraad ah, diiqadda oksidheer waxay sidoo kale u horseedi kartaa autophagy hooseeya. Urolithin A waxay leedahay awooda baabi'inta mitochondria ee waxyeelada leh iyada oo loo marayo autophagy xulashada.
Properties Waxyaabaha Antioxidant
Walwalka Oxidative wuxuu dhacaa marka ay jirto isku dheelitir la'aan udhaxaysa xagjirnimada xorta ah iyo antioxidant-ka jirka. Kuwaas xag-jirka ah ee bilaashka ah waxay badanaa la xiriiraan cudurro badan oo raaga sida cudurada wadnaha, sokorowga iyo kansarka.
Urolithins A iyo B waxay soo bandhigaan saameynta antioxidant-ka iyagoo adeegsanaya awoodooda yareynta xagjirnimada lacag la’aanta ah iyo gaar ahaan heerarka oksijiinta firfircoonida ah ee loo yaqaan 'intracellular reactive noocyada oksijiinka (ROS) iyo sidoo kale waxay xayirayaan peroxidation-ka lipid ee noocyada unugyada qaarkood.
Dheeraad ah, urolithins waxay awood u leedahay inay joojiso qaar ka mid ah enzymes oxidized, oo ay ku jiraan monoamine oxidase A iyo tyrosinase.
Properties Waxyaabaha anti-bararka
Caabuqu waa geedi socod dabiici ah oo jirkeenu la dagaallamo wax kasta oo dhaca sida infekshannada, dhaawacyada, iyo microbes. Si kastaba ha noqotee, caabuq daba-dheer ayaa waxyeello u leh jirka maxaa yeelay tani waxay la xiriirtaa cilado kala duwan sida neefta, arrimaha wadnaha, iyo kansarka. Caabuq dabadheeraad ah ayaa dhici kara sababo la xiriira caabuq ba'an oo daran, infekshanno ama xitaa xagjirnimo lacag la’aan ah oo jirka ku jirta.
Urolithins A iyo B waxay soo bandhigaan guryaha ka hortagga caabuqa iyagoo horjoogsanaya wax soo saarka nitric oxide. Waxay si gaar ah u xakameynayaan borotiinka loo yaqaan nitric oxide synthase (iNOS) iyo muujinta mRNA ee iyagu mas'uul ka ah caabuqa.
Effects Saamaynta anti-microbial
Microbes ay ku jiraan bakteeriyada, fangaska iyo fayrasku waxay si dabiici ah uga dhacaan deegaanka iyo xitaa jidhka bini-aadamka. Si kastaba ha noqotee, dhowr microbes oo loo yaqaan 'pathogens' ayaa sababi kara cudurro faafa sida hargabka, jadeecada iyo duumada.
Urolithin A iyo B waxay awoodaan inay soo bandhigaan waxqabad kahortaga dawada iyagoo ka horjoogsanaya dareemayaasha kororka. Aaladda Quorum waa hab isgaarsiinta bakteeriya u suurtagelisa bakteeriyada inay ogaato oo xakameyso geedi socodka la xiriira infakshanka sida virulence iyo motility.
Ka-hortagga glycation-ka borotiinka
Glycation waxaa loola jeedaa ku xirnaan aan-ahayn enzymatic sonkorta oo loo yaqaan lipid ama borotiin. Waa astaan-tilmaameedka muhiimka ah ee sonkorowga iyo cilado kale iyo sidoo kale gabowga.
Cilmiga borotiinka ee sareeya waa saameynta labaad ee hyperglycemia waxay door weyn ku leedahay cudurada wadnaha la xiriira sida sokorowga iyo cudurka Alzheimers.
Urolithin A iyo B waxay leeyihiin guriyaal ka hortagga glycative-ka kuwaas oo qiyaas ahaan ku-tiran kuwa ka madax bannaan waxqabadkooda antioxidant-ka.
Urolithin A faa'iidooyinka
(1) Wuxuu dheereyn karaa cimrigaaga
Urolithin A wuxuu curyaamiyaa cudurka mitophagy adoo si taxaddar leh u tirtiraya mitochondria dhaawacmay. Tani waxay sidoo kale hubineysaa dib u warshadaynta cudurka 'mitochondria' oo sifiican u shaqeynaya. Mitochondria badanaa waxay ku dhacdaa da'da iyo sidoo kale walaaca. Ka takhalusida cudurka mitochondria ee doorka leh ayaa door ka ciyaara fidinta cimrigaaga.
Daraasad lagu sameeyay Gooryaanka, urolithin Dheeraad ah oo lagu maareeyo 50 µM laga bilaabo heerka ukunta illaa geerida ayaa la ogaaday inay cimri dheereyso 45.4%.
In another study conducted in 2019 using senescent human fibroblasts, urolithin A supplement was found to exhibit anti-aging potential. It was able to increase type 1 collagen expression and also reduce the expression of matrix metalloproteinase 1.
Daraasad bini aadam ah oo yar ayaa sidoo kale muujisay in UA ay awood u yeelatay inay hagaajiso shaqada mitochondrial iyo caafimaadka qalfoofka ee dadka waayeelka ah markii afka laga qaado 500-1000mg muddo afar toddobaad ah.
(2) Caawinta kahortaga kansarka qanjirka 'prostate'
Daawada urolithins-ka iyo jiritaankooda, ellagitannins, waxay leeyihiin astaamaha anti-kansarka. Waxay awoodaan inay horjoogsadaan fiditaanka unugyada kansarka iyadoo loo marayo xarigga unugyada iyo soo saarista apoptosis. Apoptosis (Apoptosis) waxaa loola jeedaa dhimashada unugyada ee barnaamijku uu ku baabi'inayo unugyada kansarka ee suurtagalka ah iyo sidoo kale unugyada kale ee cudurka qaba.
Daraasad lagu sameeyay jiirarka jiirka ee lagu duray unugyada kansarka bini aadamka, ellagitannins metabolites (Urolithin A) ayaa la helay inay xakameyso koritaanka kansarka qanjirka 'prostate'. Daraasadda ayaa sii werisay inay ku badan tahay dheef-shiid kiimikaadka qanjirka 'prostate', unugyada xiidmaha iyo unugyada xiidmaha.
(3) Kordhinta garashada
Urolithin A wuxuu awoodaa inuu ka difaaco neerfayaasha dhimashada wuxuuna sidoo kale kicin karaa neurogenesis iyada oo loo marayo calaamadaha anti-bararka.
Daraasad ku saabsan jiirarka oo leh cillada naafanimada, urolithin A waxaa laga helay inay ka adkaato cillada garashada iyo ka ilaaliso neerfayaasha apoptosis. Tani waxay soo jeedineysaa in UA loo isticmaali karo daaweynta cudurka Alzheimers (AD).
(4) Awoodda buurnida
Daraasad la sameeyay ayaa muujisay in ellagitannins ay awood u leedahay inay horjoogsato kororka isku-darka xirmooyinka iyo sidoo kale astaamaha adipogenic sida borotiinka jawaabta korniinka hore 2 iyo sidoo kale borotiinka-isku xidha unugyada wareegga unugyada.
Urolithin A ayaa si gaar ah loo helay si loo wanaajiyo xasaasiga insulin sidaas darteed waxay ka hortageysaa horumarinta buurnaanta.
Daraasad lagu sameeyay jiirarka buurnida ee qofku buko, urolithin Dheeraad ah ayaa la helay si looga hortago buurnida ay cuntadu keento iyo culayska dheef-shiid kiimikaadka ee jiirka. Daraasadu waxay muujisay in daaweynta UA ay kordhisay kharashaadka tamarta sidaas darteed tiro jirka ka hooseysa.
Urolithin A iyo isha cuntada ee B
Urolithins looma yaqaan inay si dabiici ah looga helo ilaha cuntada laga helo. Waxay yihiin wax soo saar isbeddela acids acids-ka oo laga sameeyay ellagitannins. Ellagitannins waxaa loo beddelaa acids acids-ka iyadoo loo yaqaan 'microbiota gut' iyo aalladda 'ellagic acid' ayaa loo beddelaa dheef-shiid kiimikaadkeeda (urolithins) xiidmaha waaweyn.
Ellagitannins waxay si dabiici ah ugu dhacdaa ilaha cuntada sida rumaanka, berry ay ka mid yihiin strawberries, raspberries, cloudberries iyo blackberries, canabka muscadine, yicib, guavas, shaah, iyo lowska sida lowska iyo xabadka iyo sidoo kale cabitaanada oak-da loo yaqaan tusaale ahaan khamri cas iyo wiswis foosto geedkii.
Sidaa darteed waxaan ku soo gabagabeyn karnaa urolithin A cuntooyinka iyo urolithin B waa cunnooyinka hodanka ku ah ellagitannin. Waxaa xusid mudan in biollavailability ellagitannin uu aad u xaddidan yahay halka dheef-shiid kiimikaadkiisa labaad (urolithins) ay si fudud loo heli karo.
Urolithins excretion and wax soo saarka vary widely among individuals since the conversion from ellagitannins rely on microbiota in the gut. There are specific bacteria involved in these conversion and vary among individuals where some have high, low or no available appropriate microbiota. The food sources also vary in their ellagitannins levels. Hence the potential benefits of ellagitannins vary from one individual to the other.
Kaabayaasha Urolithin A iyo B
Urolithin A supplements iyo sidoo kale Urolithin B supplements waxaa si fudud looga helaa suuqa sida ellagitannin-hodanka ah ilaha cuntada. Kaabayaasha Urolithin A sidoo kale waa la heli karaa. Badanaa rummaannada siyaadada ah si ballaaran ayaa loo iibiyay loona isticmaalay si guul leh. Kaabayaashaan waxaa laga soosaaray miraha ama lowska waxaana loo sameeyay qaab dareere ama budo ah.
Due to variations in ellagitannins concentration in different foods, customers of urolithin a buy it putting into consideration the food source. The same applies when sourcing for urolithin B powder or liquid supplements.
Daraasadaha yar ee daaweynta bini'aadamka ee lagu sameeyay budada urolithin A ama B ma aysan soo sheegin wax saameyn ah oo daran oo ka imanaya maamulka waxyaalahan dheeriga ah
Tixraaca
- Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). "Qaddarka Dheef -shiid kiimikaadka ee Ellagitannins: Saamaynta Caafimaadka, iyo Aragtiyada Cilmi -baarista ee Cuntooyinka Wax -qabadka ee Cusub". Faallooyinka Ba'an ee Sayniska Cuntada iyo Nafaqada.
- Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 Noofambar 2009). "Urolithins, dheef-shiid kiimikaadka microbial-ka ee rummaan ellagitannins, waxay muujiyaan waxqabad antioxidant awood leh oo ku jira tijaabada unugyada ku saleysan". J Agric Food Chem.
- Bodwell, Graham; Pottie, Ian; Nandaluru, Penchal (2011). "Dib-u-dalbashada Elektiroonigga-Diels-Isku-darka Guud ee Isku-darka Urolithin M7".
